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Lung Volumetry
MedQIA provides validated measurements of lung, lobe, and segment. The measurements are made using a semi-automated Model-Based Segmentation system to maximize reproducibility. The system allows the lung to be divided into its lobes (see images below), into central and peripheral components, as well as gravity-dependent zones (anterior, middle and posterior). The accuracy of the automated lung segmentation for quantitative analyses has been validated against the gold standard of manually-edited lung boundaries (Brown 2000) and by correlation with pulmonary function tests (Brown 1999). We have also validated the accuracy of CT-based volume measures in animal models (Brown 2001). The figure below shows CT lung volumes plotted against body plethysmography in a multicenter clinical trial. These volumes are highly correlated (r=0.89).
Lung segmentation into lobes: Upper (green), Middle (red) and Lower (purples). Axial
and sagittal views are shown.
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